Studies on Chloramphenicol. III

BIOCHEMICAL STUDIES ON CHLORAMPHENICOL (CHLOROMYCETIN*) III. ISOLATION AND IDENTIFICATION OF METABOLIC PRODUCTS IN URINEt

When chloramphenicol is administered by mouth to normal human subjects, only 5 to 10 per cent of the administered dose is excreted unchanged in the urine, as determined by microbiological assay methods (3, 4). However, with calorimetric methods for aromatic nitro compounds (5), from 75 to 90 per cent of the administered dose is accounted for in 24 hour urinary excretion in man (3). The major po...

Mode of action of chloramphenicol. III. Action of chloramphenicol on bacterial energy metabolism.

X-ray studies on phospholipid bilayers. XI. Interactions with chloramphenicol.

Chloramphenicol is a widely used antibiotic with low levels of toxicity. However, scanning electron microscopy revealed morphological changes in human erythrocytes when they interacted in vitro with therapeutical concentrations of chloramphenicol. To explain this shape change, a study concerned with the possible interactions of this antibiotic with bilayers built-up of phospholipids located in ...

Mechanistic studies of Ru(III) catalyzed oxidation of antibiotic drug chloramphenicol by chloramine –T in HClO4 medium

The kinetics of oxidation of chloramphenicol by chloramine-T has been investigated over the temperature range of 308-328 K. The reaction has been found to proceed quantitatively over a wide range of experimental conditions. Oxidation of antibiotic involves four electron changes and the product of oxidation has been identified. Oxidation of antibiotic exhibits first order kinetics w.r.t [CAT]. T...

Studies on Plasma Protein. III. Malaria

Two distinct groups of cases were encountered during the study of plasma proteins in malarial patients. One was acute malaria, which showed all the features of an acute febrile infection. The other was chronic relapsing malaria, some cases were inadequately treated, and many had : hepatomegaly and splenomegaly. Plasma proteins of 40 patients, admitted in the hospital, were studied and in all of...